2016 Fiscal Year Final Research Report
Dynamic combinatorial library to prepare minimum glycoclusters for probing carbohydrate-carbohydrate interactions
| Project/Area Number |
25810105
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Toyo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 糖鎖間相互作用 / 動的コンビナトリアルケミストリー / 動的コンビナトリアルライブラリー |
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| Outline of Final Research Achievements |
In glycosphingolipid chemistry, an increasing interest has been placed on carbohydrate-carbohydrate interactions (CCIs) and it is now recognized that CCIs act as main driving forces to induce various cellular recognition events. In spite of importance of CCIs, not only fluidic nature but also fluctuations of glycosphingolipid levels on the cell surfaces make it quite difficult to investigate CCIs in a detailed manner. Simple and well-designed model systems are, therefore, highly required in this research field.
In this project, we synthesized glycosylated 1,10-bupyridines and then, used them for complexation with ferrous ion to construct the corresponding tris-bipyridine ferrous complexes having multivalent glycosylated clusters. The resultant glycoclusters showed circular dichrosm (CD) spectra characteristic for Δ-isomers. Their CD spectral changes on additions of various alkaline/alkaline-earth metal ions were monitored through CD spectral analyses.
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| Free Research Field |
糖鎖科学
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