Development of Hydrogen Cyanide and Hydrogen Sulfide Receptors

2014 Fiscal Year Final Research Report

• Project/Area Number: 25810106
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kyushu University
• Principal Investigator: WATANABE Kenji 九州大学, 薬学研究科(研究院), 特任助教 (90631937)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ポルフィリン / シクロデキストリン / シアン化水素 / 硫化水素

Outline of Final Research Achievements

A supramolecule (met-hemoCD3) was prepared by including a water-soluble porphinato iron(III) in a capsule of a O-methylated cyclodextrin dimer (Py3OCD), which was synthesized in only two steps. Ferric met-hemoCD3 showed functions similar to methemoglobin and also functioned as an antidote for cyanide poisoning. We then studied the reaction between hydrosulfide (SH-) and met-hemoCD3. Met-hemoCD3 formed a stable (SH-)-met-hemoCD3 complex in oxygen-free neutral aqueous solution, while reversible ligand exchange between (SH-)-met-hemoCD3 (Fe(III)) and O2-hemoCD3 (Fe(II)) occurred under O2 atmosphere.

Free Research Field

有機化学