Clarifying the Mechanism of Osteocyte Mechanosensing Based on Multiscale Mechanical Analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25820011
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Materials/Mechanics of materials
• Research Institution: Kyoto University (2015-2016); Osaka Prefecture University (2013-2014)
• Principal Investigator: KAMEO Yoshitaka 京都大学, ウイルス・再生医科学研究所, 助教 (60611431)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 骨 / 骨細胞 / リモデリング / マルチスケール解析 / バイオメカニクス

Outline of Final Research Achievements

The objective of this study is to clarify the mechanism of osteocyte mechanosensing that regulates bone remodeling through multiscale mechanical analysis. To begin with, we investigated the deformation of an osteocyte process induced by interstitial fluid flow in a canaliculus by performing fluid-structure interaction simulation that considers pericellular matrix. Then, we evaluated flow stimuli given to osteocytes embedded in lamellar bone tissue, which was modeled as a multi-layered poroelastic material. Finally, with the help of trabecular remodeling simulation, we clarified the effects of the microstructure of lacuno-canalicular porosity on the adaptive changes in trabecular bone morphology.

Free Research Field

バイオメカニクス