Development of vascular-like network for creating three-dimensional tissues

2014 Fiscal Year Final Research Report

• Project/Area Number: 25820383
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Properties in chemical engineering process/Transfer operation/Unit operation
• Research Institution: Kagoshima University
• Principal Investigator: TAKEI Takayuki 鹿児島大学, 理工学研究科, 准教授 (90468059)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 血管 / 再生医療 / 三次元組織

Outline of Final Research Achievements

We fabricated an engineered vascular-like network comprised assembled hollow alginate hydrogel microfibers. The distance between each flow microchannel (hollow core portions of the microfibers) were set to approximately 100 μm by using microfibers with a gel thickness of approximately 50 μm. Human hepatoblastoma cell line proliferated in the gel portions of the microfibers and maintained their specific function during perfusion culture for 7 days. These results showed that the novel vascular-like networks fabricated here have the potential to allow the creation of volumetric tissues in vitro.

Free Research Field

医用工学