2014 Fiscal Year Final Research Report
Development of a novel drug delivery system using temperature-responsive DNA aptamer
| Project/Area Number |
25820404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FURUKAWA Kazuhiro 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00644999)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | SELEX / 4’-チオDNA / DDS |
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| Outline of Final Research Achievements |
In this study, I aim at a development of novel drug delivery system using DNA. I used 4’-thio DNA instead of natural DNA to increase the biological stability. I carried out an optimization of enzymatic synthesis of 4’-thio DNA and fundamental study of SELEX to obtain 4’-thio DNA aptamer.
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| Free Research Field |
生物機能・バイオプロセス
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