Study on health concern about low-dose irradiation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25820449
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nuclear engineering
• Research Institution: Okayama University
• Principal Investigator: Kataoka Takahiro 岡山大学, 保健学研究科, 助教 (40509832)
• Research Collaborator: YAMAOKA Kiyonori 岡山大学, 大学院保健学研究科, 教授 (00314683)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ラドン / アスコルビン酸 / 一過性脳虚血 / 酸化ストレス

Outline of Final Research Achievements

We have reported that radon inhalation increases antioxidative activity in many organs of mice. On the other hand, brain damage following ischemia-reperfusion injury involves reactive oxygen species. The purpose of this study was to compare the antioxidative effects of radon with the effects of ascorbic acid. Gerbils inhaled radon or administered ascorbic acid before induction of transient global cerebral ischemia. Results showed that radon inhalation or ascorbic acid administration inhibited global cerebral ischemia induced neuron damage. Radon inhalation activated superoxide dismutase activity. These results indicated that radon inhalation at a concentration of 2000 Bq/m3 has a protective antioxidative effect against transient global cerebral ischemic injury similar to 500 mg/kg ascorbic acid treatment.

Free Research Field

放射線健康科学