2014 Fiscal Year Final Research Report
The role of autophagy in the memory process
| Project/Area Number |
25830007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Toyama |
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Principal Investigator |
SHEHATA Mohammad 富山大学, 大学院医学薬学研究部(医学), 助教 (60444197)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | オートファジー / メモリ |
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| Outline of Final Research Achievements |
It has been reported that protein degradation is necessary for the memory destabilization process; however, it is unknown whether the induction of protein degradation would enhance memory destabilization. To examine this, we induced autophagic protein degradation that we previously reported its contribution to AMPA receptors degradation after chemical LTD, suggesting its involvement in synaptic plasticity and the memory process.
In the present study, we elucidated the role of autophagy system in vivo, on both the synaptic and behavioral levels, and we provide evidence that autophagy induction enhances memory destabilization.
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| Free Research Field |
神経生理学・神経科学一般
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