Analysis of proteins expressed in the circumventricular organs

2014 Fiscal Year Final Research Report

• Project/Area Number: 25830021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: National Institute for Basic Biology
• Principal Investigator: MATSUMOTO Masahito 基礎生物学研究所, 統合神経生物学研究部門, 研究員 (30625728)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 脳室周囲器官 / 脳弓下器官 / ナトリウムチャンネル

Outline of Final Research Achievements

In animals, osmolality and sodium concentration in body fluids are continuously monitored in the circumventricular organs (CVOs) to keep it. In this study, to figure out the mechanism for the body-fluid homeostasis, we identified the proteins that specifically expressed in CVOs by transcriptome analysis. We also analyzed the expression pattern of Nax, which is known to express in CVOs, in mouse brain. We herein verified that Nax was expressed in neurons in the lateral amygdala of mice, and the interaction between Nax and PSD95 may be involved in promoting the surface expression of Nax channels in neurons.

Free Research Field

神経科学