2015 Fiscal Year Final Research Report
Analysis of prion prpagation using optical tweezers
| Project/Area Number |
25830025
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Komi Yusuke 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (20565999)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 光ピンセット / タンパク質一分子 |
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| Outline of Final Research Achievements |
I investigated the conformational space of a yeast prion protein Sup35NM using optical tweezers.Sup35NM S17R mutant had a part of common structure, but to different confomational space from Sup35NM wild type. Sup35NM S17R with EPEE mutant had similar confomational space to Sup35NM wild type.
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| Free Research Field |
生物物理
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