Mapping of centrifugal inputs onto newborn neurons in the adult mouse olfactory bulb

2014 Fiscal Year Final Research Report

• Project/Area Number: 25830032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: The University of Tokyo
• Principal Investigator: MURATA Koshi 東京大学, 医学(系)研究科(研究院), 特任助教 (10631913)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経科学 / 成体ニューロン新生 / 嗅球 / 嗅結節 / 逆行性トレーシング

Outline of Final Research Achievements

The olfactory bulb is the first relay of olfaction in the central nervous system, and unique in that new neurons are continuously generated and incorporated into the preexisting neuronal circuit throughout life. Newborn neurons in the adult mouse olfactory bulb are suggested to play a role in formation of olfactory memories. Although the incorporation of newborn neurons into the preexisting neuronal circuit is regulated by, at least in part, the centrifugal inputs from the wide areas of the olfactory cortex, the anatomical connection between newborn neurons and neurons in the olfactory cortex is unclear. In this study, I performed retrograde transsynaptic tracing using modified-rabies virus and revealed distribution of the presynaptic neurons in the olfactory cortex onto newborn neurons in the olfactory bulb.

Free Research Field

神経生物学