2014 Fiscal Year Final Research Report
Screenings of amyloid beta production inhibitor via suppression of intracellular amyloid precursor protein trafficking.
| Project/Area Number |
25830041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
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Principal Investigator |
URANO Yasuomi 同志社大学, 生命医科学部, 助教 (00546674)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 神経変性疾患 / アルツハイマー病 / 細胞内輸送 / クルクミン |
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| Outline of Final Research Achievements |
A major pathological hallmark of Alzheimer’s disease is the accumulation of Amyloid β (Aβ) in senile plaques. Aβ is generated from Amyloid precursor protein (APP) by cleavage with secretases. In this study, I found that the treatment with 24S-hydroxycholesterol, which is the brain-specific oxysterol, inhibited Aβ production by suppression of intracellular transport of APP from the endoplasmic reticulum to the Golgi.
I also conducted in vitro screening of curcumin derivatives. I identified compound which inhibited Aβ production without affecting secretase activities via suppression of intracellular APP trafficking.
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| Free Research Field |
生化学
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