2015 Fiscal Year Final Research Report
Expression and function of Siglec-H in the nervous system
Project/Area Number |
25830050
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya University |
Principal Investigator |
Konishi Hiroyuki 名古屋大学, 医学(系)研究科(研究院), 助教 (90448746)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | ミクログリア / マクロファージ / マーカー / 炎症 / グリア |
Outline of Final Research Achievements |
We examined the possibility that sialic acid binding Ig-like lectin (Siglec)-H was a novel microglial marker. We revealed that Siglec-H was expressed in microglia but not macrophages and furthermore that Siglec-H locus is useful for microglia-specific gene targeting using Siglec-H knock-in mouse. We also performed functional analysis of Siglec-H-deficient mouse and found that Siglec-H might suppress inflammatory responses of microglia after neuronal injury.
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Free Research Field |
神経損傷・再生
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