2014 Fiscal Year Final Research Report
GABAergic synaptic regulation mechanism
| Project/Area Number |
25830058
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUMIHIRO Niwa 独立行政法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (50641974)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | GABAA受容体 / IP3受容体 / 代謝型グルタミン酸受容体 / 1分子イメージング / 量子ドット / 抑制性シナプス |
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| Outline of Final Research Achievements |
GABAergic synaptic transmission regulates brain function by establishing the appropriate excitation-inhibition (E/I) balance in neural circuits. The structure and function of GABAergic synapses are sensitive to destabilization by impinging neurotransmitters. This GABAAR destabilization pathway is counteracted by the maintenance system which required Ca2+ release from ER via IP3 receptor. In this project, I found that the slow metabotropic glutamate receptor signaling activated IP3 receptor-dependent calcium release and promote GABAAR clustering and GABAergic transmission.
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| Free Research Field |
神経細胞生物学
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