2014 Fiscal Year Final Research Report
Elucidation of the mechanism of maintenance of quiescence in cancer stem cells
| Project/Area Number |
25830084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | がん幹細胞 / 細胞周期 / 静止期 / タンパク質分解 / ユビキチン / Fbxw7 |
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| Outline of Final Research Achievements |
In addition to the properties of self-renewal and multipotency, cancer stem cells share the characteristics of their distinct cell cycle status with somatic stem cells. Cancer stem cells (CSCs) are maintained in a quiescent state (G0 phase) with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CSC quiescence might therefore be expected to provide further insight into CSC behaviors and lead to the elimination of cancer. In this project, with the aim of deciphering the mechanism of maintenance of quiescence in breast cancer stem cells, we generated mouse models of this cancer and several breast cancer cell lines deficient in putative G0 maintenance factor.
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| Free Research Field |
腫瘍生物学
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