2014 Fiscal Year Final Research Report
Development of novel diagnostic methods of serrated colorectal lesions
| Project/Area Number |
25830103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Sapporo Medical University (2014)
University of Miyazaki (2013) |
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Principal Investigator |
HARADA Taku 札幌医科大学, 医学部, 訪問研究員 (60468030)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 大腸がん / メチル化 / スクリーニング |
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| Outline of Final Research Achievements |
We assessed the clinical usefulness of aberrant DNA methylation in the bowel lavage fluid (BLF) for the colorectal tumor diagnosis. We found that a panel of three genes achieved highest sensitivities to detect colorectal cancer (miR-124-3, 71.8%; LOC386758, 79.5%; SFRP1, 74.4%). A scoring system based on the number of methylated genes (M-Score) enabled CRC detection with 82% sensitivity and 79% specificity.Our data indicate that DNA methylation in BLF could be a useful biomarker for colorectal cancer screening.
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| Free Research Field |
消化器病
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