2014 Fiscal Year Final Research Report
The mechanisms of macrophage dependent vaccine
| Project/Area Number |
25830115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Mie University |
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Principal Investigator |
MURAOKA Daisuke 三重大学, 医学(系)研究科(研究院), 助教 (20608955)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | がんワクチン |
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| Outline of Final Research Achievements |
Previously we had identified that macrophage has critical role in the induction of immune responses elicited with CHP cancer vaccine (Macrophage oriented vaccine). In this study, to reveal the mechanisms of immune response induced with macrophage oriented vaccine, we compared with CHP cancer long peptide vaccine and the long peptide vaccine emulsified with IFA (classical dendritic cell dependent vaccine). As a result, we had demonstrated that the medullary macrophage has a critical role in macrophage oriented vaccine. Furthermore, we had shown the detailed mechanism which is involved in the efficacy of this vaccine system.
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| Free Research Field |
腫瘍免疫
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