2015 Fiscal Year Final Research Report
anti-tumor effect mediated the inhibition of regulatory T cell migration
| Project/Area Number |
25830117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Okayama University |
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Principal Investigator |
Eikawa Shingo 岡山大学, 医歯(薬)学総合研究科, 助教 (40635265)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 制御性T細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated whether the regulation of Treg migration and accumulation into tumor tissues leads to reduce tumor growth using a peptide which blocks chemoattractants of IL-8. We previously reported rather high production of IL-8 in all tumors and IL-6 in one lung cancer, the malignant mesothelioma, and the malignant melanoma and observed enrichment of Foxp3+ CD4 Tregs in migrated T cells to both IL-6－ and IL-8－ producing tumors. Marked induction of CXCR1 expression on Foxp3+ CD4 Tregs by IL-6 followed by IL-8－mediated migration appeared to be responsible for enriched migration.
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| Free Research Field |
腫瘍免疫
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