2014 Fiscal Year Final Research Report
Intracellular self-organization of actin cytoskeleton
| Project/Area Number |
25830147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
FUJITA Masashi 独立行政法人理化学研究所, 生命システム研究センター, 研究員 (80564749)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 細胞骨格 / アクチン / ミオシン / 細胞動態 / RhoGAP |
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| Outline of Final Research Achievements |
Actin filaments and myosin motor form network at the cell cortex and generate contractile forces. This actomyosin network form pulsatile foci in the cell cortex of the one-cell embryos of the nematode C. elegans. In this study, I investigated how the foci structure is regulated. I found that RhoGAP proteins RGA-3/4 colocalize to the actomyosin foci. Experiments showed that RGA-3/4 regulate the size and disassembly of actomyosin foci.
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| Free Research Field |
システム生物学
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