Mechanisms underlying fate transitions of neural stem cells by regulation of chromatin state

2015 Fiscal Year Final Research Report

• Project/Area Number: 25840003
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Molecular biology
• Research Institution: The University of Tokyo
• Principal Investigator: Kishi Yusuke 東京大学, 薬学研究科(研究院), 助教 (00645236)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経幹細胞 / クロマチン / HMGA

Outline of Final Research Achievements

One of the fundamental questions in understanding tissue development is how multipotent progenitors/tissue stem cells give rise to various cell types in a defined order to achieve appropriate tissue organization. Neural stem/progenitor cells (NPCs) attract much attention since these cells give rise to a sequence of neuronal and glial cell types in a developmental-stage dependent manner with striking precision. Previously, we have shown that high mobility group A (HMGA) proteins play pivotal roles in driving fate switches of NPCs during neocortical development. In this study, we identified the genes Imp2, which is upregulated by HMGA proteins, as novel regulators of neurogenic potential of NPCs.

Free Research Field

分子生物学