Structure and function of moyamoya disease-associated protein, mysterin

2014 Fiscal Year Final Research Report

• Project/Area Number: 25840024
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural biochemistry
• Research Institution: Kyoto Sangyo University
• Principal Investigator: MORITO Daisuke 京都産業大学, 総合生命科学部, 研究員 (20514251)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ミステリン / モヤモヤ病 / AAA+タンパク質 / ユビキチン

Outline of Final Research Achievements

We demonstrated that mysterin contains enzymatically active AAA+ ATPase modules, forms large troidal oligomer through these modules, and dynamically changes its structural state. Furthermore, we demonstrated that mysterin is indispensble for neuro, muscular, and vascular development in vivo using zebrafish model. The two enzymatic activities of mysterin are both essential for this function.

Free Research Field

構造生物化学