2014 Fiscal Year Final Research Report
The role of polymeric osteopontin on inflammation
| Project/Area Number |
25840034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 生理活性物質 / オステオポンチン / 重合 / 炎症 |
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| Outline of Final Research Achievements |
In this study, I examined to reveal the role of polymerized osteopontin (catalyzed by protein-crosslink enzyme, transglutaminase 2) on inflammation. As a result, it was cleared that osteopontin and transglutaminase 2 were up-regulated by pro-inflammatry cytokine, TGF-β1 and the former was polymerized on cell membrane fraction by the latter. I was also successful in the generation on transgenic mice expressed polymerization-incompetent mutant osteopontin specific in lung.
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| Free Research Field |
免疫学、分子生物学、細胞接着分子、細胞外マトリックス
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