2014 Fiscal Year Final Research Report
The function of a novel ER modulating factor, Pecanex in Notch signaling
| Project/Area Number |
25840074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAKAWA Tomoko 大阪大学, 理学(系)研究科(研究院), 助教 (20645402)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | Notchシグナル / 小胞体 / ショウジョウバエ |
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| Outline of Final Research Achievements |
Notch signaling regulates many cell-fate decision in multi-cellular organism and its defects causes various diseases in human like cancer. pecanex (pcx) is a component of Notch signaling. My study revealed that Pcx is localized to the ER and required for the ER morphogenesis. To further understanding of pcx molecular function, I screened pcx modifiers and identified 6 candidate genes. I obtained 4 genes, which encodes known Notch signaling components, Nsf2 encoding an ATPase required for the vesicle fusion and jim lovell encoding a transcription factor. And I showed that these candidate genes genetically interact with pcx.
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| Free Research Field |
細胞生物学
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