ERdj5 mediated ER homeostatic mechanism

2014 Fiscal Year Final Research Report

• Project/Area Number: 25840079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cell biology
• Research Institution: Kyoto Sangyo University
• Principal Investigator: USHIODA Ryo 京都産業大学, 総合生命科学部, 助教 (30553367)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: タンパク質品質管理 / レドックス / 小胞体関連分解 / カルシウム恒常性

Outline of Final Research Achievements

We declared that ERdj5 interacts with SERCA2, which is a Ca2+ uptake pump, through the mixed disulfide bond. It suggests that ERdj5 reductase activity promotes SERCA2 pump function. Recently, we found the oligomer formation of ERdj5 depending on Ca2+ concentration in ER. These oligomer formation regulates the interaction with SERCA2. Additionally, we reported that accumulations of collagen by Hsp47 deficient lead to Cell death through ER stress by Autophagy inhibition. Especially, these cell death links to therapeutic for liver fibrosis (K. Kawasaki, R.Ushioda et al. 2015 J. Biol. Chem.)

Free Research Field

細胞生物学