2015 Fiscal Year Final Research Report
Study of the mode of newt myocardial regeneration based on identification of the cell linage and functional analysis of the cell cycle related genes.
| Project/Area Number |
25840086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | イベリアトゲイモリ / 心臓再生 / 心筋細胞 / 細胞系譜 / トランスジェニック / ゲノム編集 |
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| Outline of Final Research Achievements |
Using Iberian ribbed newt that is useful a model animal for regeneration biology, we established a cell lineage tracing system by genetic labeling. We showed the pre-existing cardiomyocytes proliferated during cardiac regeneration in the newts. We reported that TALEN-mediated gene targeting and an infrared laser mediated local gene induction by IR-LEGO system in the P. waltl. Moreover, we prepared basic data for genome editing in the newts in order to establish conditional knock-out system that enable more detailed analysis in organ regeneration.
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| Free Research Field |
再生生物学
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