2014 Fiscal Year Final Research Report
Inheritance of Transcriptional Dynamics
| Project/Area Number |
25840095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Toho University (2014)
Institute of Physical and Chemical Research (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 転写 / ライブイメージング / 細胞分化 / 周期性 / ゆらぎ / クロマチン修飾 / 遺伝子発現動態 |
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| Outline of Final Research Achievements |
In a forward genetic screen, 4 mutants that exhibited high heterogeneity in gene expression were isolated. To investigate the inheritance of active transcriptional states between mother and daughter cells in the mutants, I have directly recorded a dynamic nature of transcription in individual living cells through mitosis. During these analyses, synchronized oscillatory transcription events were observed at 5h development and then molecular mechanisms of the oscillatory events were analyzed in detail.
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| Free Research Field |
発生生物学
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