2015 Fiscal Year Final Research Report
Regulatory mechanism of hypothalamus-pituitary system as a basis of vertebrate's evolution
| Project/Area Number |
25840115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Shizuoka University |
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Principal Investigator |
OKADA Reiko 静岡大学, 理学部, 講師 (50386554)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 視床下部 / 下垂体 / 両生類 |
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| Outline of Final Research Achievements |
Hypothalamus-pituitary-thyroid gland (HPT) axis plays an important role to maintain body temperature in mammals. Thyrotropin-releasing factor (TRH) is a major factor that enhances the release of thyroid-stimulating hormone (TSH) from the pituitary in mammals, whereas it mainly acts as a prolactin-releasing factor in amphibians. In this study, it was revealed that expression of TRH precursor mRNA in the frog hypothalamus was increased by cold stimulation as in mammals. The discrepancy in the role of hypothalamic factors between amphibians and mammals is discussed in relation to metamorphosis and thermoregulation.
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| Free Research Field |
比較内分泌学
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