2015 Fiscal Year Final Research Report
The Chromatoidmics analysis for clarification of spermatogenesis process
| Project/Area Number |
25840119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Nagasaki International University |
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Principal Investigator |
Fujii Yuki 長崎国際大学, 薬学部, 助教 (80610063)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | クロマトイドボディー / Ago2 / ヌアージュ / 免疫電顕 |
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| Outline of Final Research Achievements |
The localization of spermatogenic protein, Argonaute 2 (Ago2) function to interfer the transcription was identified on the rat testis. Ago2 was localized germ cell specific organelle, “Nuage” during the development on spermatocyte to spermatid. Moreover, the co-localization of Ago2 and lysosome membrane protein, LAMP2 in the clear vesicles surrounded on the Chromatoid body was identified by the Immunoelectron microscopic analysis in the late stage of spermatid. These results suggest that not only Ago2 modulate transcription of RNA in nuage structure but also related on the lysosome pathway in the late CB.
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| Free Research Field |
糖鎖生物学
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