Elucidation of epigenetic mechanism that regulates a neural circuit for C. elegans behavioral plasticity

2014 Fiscal Year Final Research Report

• Project/Area Number: 25840124
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Kyoto University
• Principal Investigator: SUGI Takuma 京都大学, 物質-細胞統合システム拠点, 助教(特任) (70571305)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 記憶 / エピジェネティクス / 線虫C. elegans

Outline of Final Research Achievements

In this study, I investigated a mechanistic relationship between epigenetics and behavioral memory in C. elegans. I initially developed a multiplexed optical system to genetically analyzed C. elegans mechanosensory habituation in a high-throughput manner. Then, using this system, I identified two interneurons involved in memory formation, and an epigenetic factor important for memory formation.

Free Research Field

生物物理学