A study on the food development for the prevention of tumor angiogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25850086
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: TSUDUKI Tsuyoshi 東北大学, (連合)農学研究科(研究院), 准教授 (00404848)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 血管新生 / リノレン酸 / エレオステアリン酸 / 共役リノレン酸 / 共役リノール酸 / キリ / ニガウリ

Outline of Final Research Achievements

In the current study, the antiangiogenic effects of ESA were investigated in vitro. ESA also inhibited the formation of capillary-like networks by human umbilical vein endothelial cells (HUVEC) and moderately inhibited HUVEC proliferation and migration in a dose-dependent manner. The mechanism by which ESA inhibited angiogenesis was through activation of peroxisome proliferator-activated receptor (PPAR) γ and induction of apoptosis in HUVEC. We thus demonstrated that, like troglitazone, ESA is a PPARγ ligand, and that it activates PPARγ induces apoptosis in HUVEC, and inhibits angiogenesis. Our findings suggest that ESA has potential use as a therapeutic dietary supplement and medicine for minimizing tumor angiogenesis.

Free Research Field

食品機能学