The mechanisms by which protein malnutrition increases circulating adiponectin levels in rats

2015 Fiscal Year Final Research Report

• Project/Area Number: 25850095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Nippon Medical School
• Principal Investigator: Toyoshima Yuka (豊島由香) 日本医科大学, 付置研究所, 講師 (70516070)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アディポネクチン / 低タンパク質栄養 / 脂肪細胞

Outline of Final Research Achievements

Adiponectin is a protein that is mainly secreted from adipocytes and exhibits an antidiabetic property, which enhances insulin action. Our previous studies showed that protein malnutrition caused increases in circulating adiponectin levels in growing rats. In this study, we found that the enhancement of adiponectin secretion from adipocytes and/or the suppression of its degradation in the blood result in the elevation of circulating adiponectin levels in protein-malnourished rats. Furthermore, it was suggested that lower circulating insulin and insulin-like growth factor-1 contribute to enhance adiponectin secretion from adipocytes under protein malnutrition.

Free Research Field

分子栄養学