2014 Fiscal Year Final Research Report
Regulation of autophagy by APOBEC2 and its physiological roles in skeletal muscle
| Project/Area Number |
25850218
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Integrative animal science
|
|---|
| Research Institution | Utsunomiya University |
|---|
Principal Investigator |
SATO YUSUKE 宇都宮大学, 農学部, 助教 (50589520)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 骨格筋 / APOBEC2 / オートファジー / ミトコンドリア / 代謝 |
|---|
| Outline of Final Research Achievements |
Autophagy is essential for maintaining muscle mass. Dysregulation of autophagy is known to cause myopathy and atrophy. In the present study, we investigated whether APOBEC2, a muscle specific AID/APOBEC deaminase family, deficiency promotes autophagy/mitophagy in skeletal muscle. We found that autophagy/mitophagy up-regulation and metabolic dysregulation in APOBEC2 deficient muscle. Further studies should be done to elucidate the regulatory mechanisms of APOBEC2 mediated autophagy and its molecular function in skeletal muscle.
|
| Free Research Field |
農学
|
