2014 Fiscal Year Final Research Report
Development of a Bronsted Acid-Promoted Ene-Ynamide Cyclization
| Project/Area Number |
25860006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAOKA Yousuke 京都大学, 薬学研究科(研究院), 助教 (60624723)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 複素環合成 / 天然物合成 / イナミド / 抗マラリア薬 |
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| Outline of Final Research Achievements |
We developed a Bronsted acid-promoted arene-ynamide cyclization to construct the 3H-pyrrolo[2,3-c]quinolines. This methodology enabled facile access to marinoquinolines A and C and aplidiopsamine A.
Futhermore, we now develop the efficient medium ring heterocycles with ynamides catalyzed by a Bronsted Acid. We investigate to apply this methodology to the total synthesis of complex molecules for a medicinal chemistry.
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| Free Research Field |
有機化学
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