2015 Fiscal Year Final Research Report
Development of asymmetric sequential reactions for molecular syntheses using Lewis base-chlorosilane complex as reactive species
| Project/Area Number |
25860008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 有機合成化学 / 有機分子触媒 / 不斉合成 / 薬学 / 多成分連結反応 / アルドール反応 / ホスフィンオキシド / ケイ素化合物 |
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| Outline of Final Research Achievements |
Hypervalent silicon complexes, which are formed from chiral Lewis bases and chlorosilanes, are chemical species bearing both electrophilic sites and nucleophilic sites, and facilitie various stereoselective transformations.
I developed asymmetric sequential reactions involving double aldol reaction and halo aldol reaction using the sequential formations of hypervalent silicon complexes in the reaction. Moreover, applying the asymmetric reactions to molecular syntheses involving (-)-ericanone and optically active pyranones or oxetanes, we demonstrated utilities of these reactions.
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| Free Research Field |
有機化学
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