Sugar-responsive molecular necklaces and their application for an artificial pancreas

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860027
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Josai University
• Principal Investigator: Egawa Yuya 城西大学, 薬学部, 准教授 (90400267)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: シクロデキストリン / ボロン酸 / 糖応答性 / インスリン / 超分子 / シュードポリロタキサン / ポリシュードロタキサン / 刺激応答性

Outline of Final Research Achievements

We have improved a sugar response of an artificial pancreas system based on a molecular necklace structure. Our previous system was composed of two materials. One was a bead-like molecule modified with a sugar sensor moiety, phenylboronic acid-modified γ-cyclodextrin (PBA-γ-CyD). The other was a chain polymer modified with naphthalene and insulin at each terminal, naphthalene-polyethylene glycol-insulin (Naph-PEG-Ins). The Naph-PEG-Ins/PBA-γ-CyD molecular necklace was poorly water soluble at pH 7.4; however, sugar addition induced disintegration of the molecular necklace, and the release rate of Naph-PEG-Ins was accelerated. In this study, the sugar sensor moiety was replaced by nitrophenylboronic acid (NPBA). The molecular necklace containing NPBA showed a better sugar response due to its stronger sugar affinity and its three-dimensional arrangement in the molecular necklace.

Free Research Field

物理化学