2015 Fiscal Year Final Research Report
Nose-to-Brain Delivery of Biopharmaceuticals via Non-covalent Strategy with Cell-Penetrating Peptides
| Project/Area Number |
25860031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Research Collaborator |
TAKEDA Mariko (MORISHITA Mariko)
WATANABE Yasuyoshi
KANAYAMA Yousuke
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脳内デリバリー / 経鼻投与 / バイオ薬物 / 細胞膜透過ペプチド / インスリン / インクレチン |
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| Outline of Final Research Achievements |
The biopharmaceuticals are required to permeate through blood-brain barrier (BBB) for achieving the efficient therapeutic effect in central nervous system (CNS). In this study, we therefore tried to develop the successful strategy for brain delivery of biopharmaceuticals via the direct nose-to-brain transport, which can bypass the BBB. The biopharmaceuticals coadministered intranasally with cell-penetrating peptides (CPPs) was efficiently delivered to the brain parenchyma including cerebral cortex and hippocampus, and eventually showed the therapeutic actions for CNS disorders. This study opened new avenues for developing a novel CNS pharmacotherapy with biopharmaceuticals.
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| Free Research Field |
薬剤学、ドラッグデリバリー
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