2015 Fiscal Year Final Research Report
Roles of chondroitin sulfate interacting with RAGE involved in tumor and Alzheimer's disease
| Project/Area Number |
25860037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Research Collaborator |
SUGAHARA KAZUYUKI 北海道大学, 大学院先端生命科学研究院, 名誉教授 (60154449)
YAMADA SHUHEI 名城大学, 薬学部, 教授 (70240017)
IKEGAWA SHIRO 理化学研究所, 骨関節疾患研究チーム, 主任研究員 (30272496)
MATSUMOTO NAOMICHI 横浜市立大学, 医学研究科, 教授 (80325638)
MIYAKE NORIKO 横浜市立大学, 医学研究科, 准教授 (40523494)
KOSHO TOMOKI 信州大学, 医学部附属病院, 准教授 (90276311)
Janecke Andreas Innsbruck Medical University
Nürnberg Peter University of Cologne
Kennerknecht Ingo Institute of Human Genetics, Westfälische Wilhelms, Universität
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | コンドロイチン硫酸 / RAGE / 癌 / アルツハイマー病 / プロテオグリカン / ヘパラン硫酸 / 骨・皮膚疾患 |
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| Outline of Final Research Achievements |
To understand the roles of chondroitin sulfate and Receptor for Advanced Glycation-End product (RAGE) in tumor metastasis, RAGE-knockout mice were utilized for the analysis. We revealed that RAGE and chondroitin sulfate are involved in tumor metastasis and neuritogenesis based on the analyses of RAGE-knockout mice. We developed the production of recombinant RAGE using Pichia pastoris. Furthermore, we have identified a patient with short stature and bone dysplasia caused by mutation in the genes encoding chondroitin sulfate-biosynthetic glycosyltransferase.
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| Free Research Field |
糖鎖生物学
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