Regulation of primary cilia formation cycle by Kif24

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: KOBAYASHI Tetsuo 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (80433994)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 一次繊毛 / 中心小体

Outline of Final Research Achievements

Primary cilia function as cell’s antenna and malfunction of this organelle causes various diseases called ciliopathy. Once cells exit cell cycle and go to quiescent phase, a primary cilium is formed. On the other hand, the primary cilium disappears when cells reenter to cell cycle. However, molecular mechanisms underlying assembly and disappearance of primary cilia are unclear. Here, we identified Talpid3 to associate with centriolar proteins CP110 and Kif24, requisite proteins for regulation of primary ciliogenesis. We showed that Talpid3 and Cep290, a causal protein of ciliopathies, play an essential role in early stage of primary ciliogenesis by controlling ciliary vesicle formation.

Free Research Field

細胞生物学