2015 Fiscal Year Final Research Report
Study on the role of protein arginine methyltransferase 5 in cardiac hypertrophy
| Project/Area Number |
25860052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
|
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 心肥大 / 心不全 / アルギニンメチル化酵素 / 転写 |
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| Outline of Final Research Achievements |
Heart failure is one of the leading causes of death in industrialized countries, and cardiac hypertrophy is a risk factor for heart failure. We have demonstrated that PRMT5, a protein arginine methyltransferase, is involved in the promotion of cardiac hypertrophy and the development of heart failure. These results indicate that PRMT5 is a possible molecular target for heart failure therapy.
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| Free Research Field |
生物系薬学
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