2014 Fiscal Year Final Research Report
Physiological and pathophysiological roles of lysophosphatidylinositol
| Project/Area Number |
25860054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 脂質生化学 / リゾリン脂質 / Gタンパク質共役型受容体 |
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| Outline of Final Research Achievements |
GPR55 is an orphan G protein-coupled receptor and a putative novel type of cannabinoid receptor. Its endogenous ligand is lysophosphatidylinositol (LPI). This study revealed that high levels of GPR55 mRNA were observed in the immune organs such as spleen and lymph nodes and the digestive organs such as small intestine and large intestine. The expression of GPR55 mRNA in the immune cells was next examined. High levels of GPR55 mRNA expression were observed in T and B cells. LPI enhanced the IgG secretion from B cell lines via a GPR55 dependent manner. It seems possible that GPR55 plays important physiological and/or pathophysiological roles in the function of the immune system.
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| Free Research Field |
医歯薬学
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