Elucidation of sPLA2 network as a regulator of metabolic inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860059
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: SATO Hiroyasu 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (50546629)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 分泌性ホスホリパーゼ / メタボリックシンドローム / 慢性炎症 / 脂質代謝

Outline of Final Research Achievements

To elucidate the role of secreted phospholipase A2 (sPLA2) in metabolic syndrome, we analyzed high fat diet-fed mice knockout mice for individual sPLA2 isoforms. We found that (1) sPLA2-IIE altered minor lipoprotein phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), and moderately facilitated lipid accumulation in adipose tissue and liver. (2) sPLA2-IID plays a role in amelioration of metabolic syndrome. (3) sPLA2-III facilitated recruitment of immune cells such as mast cells in adipose tissue. (4) sPLA2-X plays a role in amelioration of metabolic syndrome.

Free Research Field

医歯薬学