Involvement of neuroinflammation in the negative affective component of chronic pain: Effect of resolvin D1, an anti-inflammatory lipid mediator

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860060
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: DEYAMA Satoshi 北海道大学, 薬学研究科(研究院), 助教 (30634993)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: レゾルビンD1 / レゾルビンD2 / 抗うつ作用 / mTOR経路 / ω-3系脂肪酸 / DHA

Outline of Final Research Achievements

In the present study, we aimed to assess the effects of resolvin D1 (RvD1), an anti-inflammatory lipid mediator, on chronic pain-induced neuroinflammation and the negative affective states. Intracerebroventricular injections of RvD1 or resolvin D2 (RvD2) exerted antidepressant-like effects against lipopolysaccharide-induced depression-like behavior, a rodent model of inflammation-induced depression, via activation of mTOR signaling. Further investigations are required to verify whether RvD1 and RvD2 improve the negative affective states in a chronic pain model.

Free Research Field

神経薬理学