2014 Fiscal Year Final Research Report
Mechanism of nucleotide accumulation and release in blood cells
| Project/Area Number |
25860062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
HIASA Miki 岡山大学, 医歯(薬)学総合研究科, 助教 (30587720)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 血小板 / ヌクレオチド / ATP / VNUT / 化学伝達 |
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| Outline of Final Research Achievements |
The mechanisms of nucleotide accumulation and release in blood cells are unclear. In this study, we analyzed vesicular nucleotide transporter (VNUT) function and localization in platelet. VNUT was localized in dense granules and play crucial roles in nucleotide accumulation and release in platelets. We also found an effective VNUT inhibitor, glyoxylate.
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| Free Research Field |
薬学
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