2015 Fiscal Year Final Research Report
Therapeutic strategy for oxaliplatin-induced neuropathy by mulecular targeting drugs
| Project/Area Number |
25860071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | オキサリプラチン / 末梢神経障害 / 分子標的薬 |
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| Outline of Final Research Achievements |
I show that oxaliplatin induces the neuropathy through the activation of PKC/ERK/c-Fos pathway in lumber spinal cords. In addition, PKC inhibitor suppressed the oxaliplatin-induced neuropathy via PKC pathways. These findings suggest that PKC inhibitors are potentially useful for oxaliplatin-induced neuropathy.
As well, These results are summarized as section of presented paper.
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| Free Research Field |
薬物治療学
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