2014 Fiscal Year Final Research Report
Novel therapeutic approach using the endogenous antitumor substance in renal cell carcinoma
| Project/Area Number |
25860072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 腎臓癌 / プロテオミクス |
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| Outline of Final Research Achievements |
Renal cell carcinoma (RCC) is clinically refractory cancer for resistant to anticancer drug. In this study, to explore the novel therapeutic modality for RCC, we investigated the anticancer effect of endogenous anticancer substance 15-Deoxy-Δ12, 14-Prostaglandin J2 (15d-PGJ2) and identified the target protein of 15d-PGJ2. The topoisomerase II inhibitor etoposide exhibited cytotoxic effects synergistically with 15d-PGJ2. The 55 target proteins for 15d-PGJ2 were identified by using proteomic approach (e.g. glycolytic enzymes, cytoskeletal proteins and molecular chaperons).
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| Free Research Field |
医歯薬学
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