Development of new anti-HIV drug lead from anti-HIV natural product biyouyanagin A

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Natural medicines
• Research Institution: The University of Tokushima (2014); Hokkaido University (2013)
• Principal Investigator: TANAKA Naonobu 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (40455598)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 抗HIV薬リード / 天然物 / ビヨウヤナギンA

Outline of Final Research Achievements

Precursors for analogues of an anti-HIV natural product, biyouyanagin A, were prepared from natural sources. Bromopyrrole alkaloids (from a marine sponge of Agelas sp.), oxylipins (Plakortis sp.), indole alkaloids (Hyrtios sp.), secoiridoid glucosides (from Gentiana plant) and diterpenes (from Isodon plant) were isolated from marine sponges and plants as precursors of the terpenoid moiety, while hyperolactones were isolated from a plant Hypericum chinense as precursors of spirolactone moiety. Some biyouyanagin A analogues were obtained from bromopyrrole alkaloids and hyperolactones by the [2+2] photocycloaddition reaction.

Free Research Field

天然物化学、生薬学