2015 Fiscal Year Final Research Report
The research of intestinal metabolism experimental model built-in biological activity evaluation and liver protection substances from natural materials
| Project/Area Number |
25860086
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腸内細菌 / 薬物代謝 / 天然物 / 肝保護 |
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| Outline of Final Research Achievements |
A lot of separating the glycosides from natural products that are likely to have hepatoprotective activity , was carried out metabolism studies using human-derived intestinal bacterial strain for those compounds .The compound obtained from their natural products , the evaluation of liver protective activity was carried out in terms of their metabolites .All glycoside isolated was found to undergo metabolism.By was carried out metabolism experiments using the 30 species of the human intestinal bacteria strain , it has also been found , such as each of the metabolic rate . As a result of the measurement of liver protective activity , significantly increased activity in the quercetin of the final metabolites of rutin and the eriodictyol of the final metabolites of eriocitrin was observed . Metabolism by intestinal bacteria has been suggested to affect the activation of activity .
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| Free Research Field |
天然薬物学
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