2015 Fiscal Year Final Research Report
Asymmetric syntheses of various iminofuranoses having a side chain at C1 position and their biological evaluation as enzyme inhibitors
| Project/Area Number |
25860088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHATA Hiroki 東北薬科大学, 薬学部, 教授 (00109109)
YOSHIMURA Yuichi 東北薬科大学, 薬学部, 教授 (00230813)
KATO Atsushi 富山大学, 付属病院薬剤部, 准教授 (60303236)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 医薬品化学 / イミノ糖 / 医薬分子設計 / 酵素阻害活性物質 / α-グルコシダーゼ阻害薬 / ゴーシェ病治療薬 / ケミカルシャペロン療法 |
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| Outline of Final Research Achievements |
This research program aimed at developing new potent and selective glucosidase inhibitors. I have focused on the α-1-C-substituted L- and D- iminofuranose derivatives.The asymmetric syntheses of α-1-C-alkyl D- and L-iminofuranose derivatives were achieved. Their inhibitory activities were measured.
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| Free Research Field |
医薬品化学
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