2014 Fiscal Year Final Research Report
Development of therapeutic and diagnostic methods for gastric MALT lymphoma by infection with Helicobacter heilmannii
| Project/Area Number |
25860099
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental and hygienic pharmacy
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | Helicobacter / heilmannii / MALTリンパ腫 |
|---|
| Outline of Final Research Achievements |
In this study, to determine the malignant factor of gastric MALT lymphoma by infection with H. heilmannii, gene expression profiling analysis in the serum and liver of chronic infected mice was performed using microarray method. The results revealed that 15 genes, which were upregulated in both serum and liver, were determined. In addition, we investigated the therapeutic effect of mutant CTLA4-Ig, which is strong blocker of CD86-CD28 interaction. Administration of mutant CTLA4-Ig antigen attenuated the gastric MALT lymphoma formation and the mRNA expression of the marker gene of the gastric MALT lymphoma component B cells.
|
| Free Research Field |
病態生理 消化器
|
