2014 Fiscal Year Final Research Report
Investigation of thymic aging effect of environmental compounds via PPAR signal passway
| Project/Area Number |
25860102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 胸腺 / DEHP / PFOA / PPARgamma |
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| Outline of Final Research Achievements |
We investigated the effect of environmental chemicals on thymic aging via PPAR gamma. di-(2-ethylhexyl)-phthalate (DEHP) administration in the C57BL/6 mice increased adipose and liver weight but had not changed thymus weight. perfluorooctanoic acid (PFOA) administration in the C57BL/6 mice decreased body, thymus and spleen weight, increased liver and adipose weight. Furthermore, DEHP and PFOA enhanced the mRNA levels of PPAR gamma and aP2 in the apipose and thymus. These results suggest that DEHP and PFOA promotes thymic aging via PPAR gamma.
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| Free Research Field |
分子毒性学
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