2014 Fiscal Year Final Research Report
Relationship between neurotoxicity and the chemical structures of amphetamines
| Project/Area Number |
25860103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 覚せい剤類似化合物 / 神経毒性 / プロテオミクス |
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| Outline of Final Research Achievements |
Little information is available on the basic toxicological properties of designer amphetamines. We evaluated relationship between the toxicity and their chemical structures of amphetamines substituted with flour and methoxy groups. In this study, we suggested that amphetamines have similar or larger ①cytotoxicity, ②inhibitory effect of neurite outgrowth, ③change the amount of monoamines in mouse brain and ④change the proteome in mouse brain compare to AP and MA treatment. In order to avoid abuse from amphetamines, it is necessary to development of laws for these analogs rapidly.
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| Free Research Field |
毒性学
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